Application: Trans ISRIB (integrated stress response inhibitor) as a drug, imparts resistance to the cells against the downstream effects of eukaryotic initiation factor 2 (eIF2)α phosphorylation such as activating transcription factor 4 (ATF4) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) induction. Trans ISRIB is a blood- brain barrier penetrant, potent and selective inhibitor of integrated stress response (ISR) that impairs adaptation to ER stress. Trans ISRIB is a potent inhibitor of PERK signaling, which potently reverses the effects of eIF2a phosphorylation and restores the cells translation capacity. Trans ISRIB enhances cognitive memory in rodents.Trans ISRIB (integrated stress response inhibitor) has been used as an inhibitor of integrated stress response.
Product details
Product name: ISRIB
Trade Name: ISRIB
Purity: >99.0%
Molecular Formula: C22H24Cl2N2O4
Molecular Weight: 451.34g/mol
Appearance: White powder
Storage:After reconstitution store at 2°C - 8°C
