Acetyl Hexapeptide-38 is a synthetic acetylated hexapeptide with the sequence Ac-Ser-Val-Val-Val-Arg-Thr-NH2. A breakthrough in cosmetic peptide technology, it’s designed to target skin aging signs, reduce dynamic wrinkles, and restore facial volume by boosting adipogenesis and collagen synthesis. This high-purity raw powder is ideal for formulating advanced skincare products, from anti-wrinkle serums to volume-enhancing creams.
Restores Facial Volume: Upregulates PGC-1α expression by 61.1%, stimulating adipocyte differentiation and lipid accumulation to plump cheeks, tear troughs, and breasts.
Boosts Collagen Synthesis: Targets dermal fibroblasts to enhance collagen production, improving skin elasticity and firmness.
Repairs Skin Barrier: Reduces transepidermal water loss (TEWL) by 22.4%, strengthening the skin’s protective layer and soothing irritation.
Non-Irritating & Safe: Non-comedogenic (rating 0), suitable for all skin types, including sensitive and acne-prone skin.
Mechanism of Action
Neuro-Relaxing Pathway: Competitively inhibits SNAP-25 protein and blocks voltage-gated calcium channels, reducing acetylcholine release and relaxing facial muscles to prevent wrinkle formation.
Adipogenesis Activation: Upregulates PGC-1α, a key regulator of fat metabolism, promoting preadipocyte differentiation and lipid storage in targeted areas for natural volume restoration.
Collagen Stimulation: Activates skin repair mechanisms, increasing dermal collagen content and improving tissue structure to reduce sagging.
Applications
Anti-Aging Skincare: Serums, creams, and eye treatments for wrinkle reduction and skin firmness.
Volume-Enhancing Products: Cheek plumpers, breast enhancement creams, and lip fillers.
