Nonapeptide-1

No.Cosmetic Raw Powder-4

Nonapeptide-1 (Melanostatine-5) is a biomimetic nonapeptide designed to target the root cause of hyperpigmentation. As a selective MC1R antagonist, it competitively binds to melanocyte receptors, blocking α-MSH signaling and inhibiting melanin synthesis at the source—before tyrosinase activation. This gentle yet powerful peptide brightens skin, fades dark spots, and evens tone without irritation, ideal for sensitive skin and long-term use.

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Key Benefits

✨ Targeted Depigmentation: Inhibits melanin production at the MC1R receptor level (IC50 = 2.5 nM), outperforming traditional tyrosinase inhibitors.
✨ Brightens & Evens Tone: Reduces hyperpigmentation, age spots, freckles, and post-inflammatory discoloration for a radiant complexion.
✨ Gentle & Safe: Non-toxic, non-irritating, and suitable for all skin types, including sensitive skin.
✨ Stable & Versatile: Stable in formulations (pH 6–8) and compatible with most skincare ingredients.

Mechanism of Action

Blocks α-MSH Binding: Competes with α-MSH for MC1R receptors on melanocytes, preventing signal transduction.
Inhibits cAMP Production: Reduces intracellular cAMP, suppressing tyrosinase activation and melanin synthesis.
Reduces Melanosome Dispersion: Limits melanosome transfer to keratinocytes, preventing dark spot formation.

Applications

Skincare Formulations: Whitening serums, brightening creams, spot correctors, toners, and masks.
Professional Use: Spa treatments, mesotherapy, and custom skincare blends.
Recommended Addition Rate: 10–200 ppm (0.001–0.02%) in final formulations.

Storage & Shelf Life

Storage: -20°C in a dry, dark place; avoid frequent thawing.
Shelf Life: 2 years unopened; 6 months after opening (under proper storage).

Quality Assurance

High Purity: ≥98% HPLC-tested for consistent efficacy.
GMP Certified: Manufactured in GMP-compliant facilities with strict quality control.
COA Available: Certificate of Analysis provided upon request.

Why Choose Our Nonapeptide-1 Powder?

Our premium-grade Nonapeptide-1 delivers potent, safe, and stable brightening results for your skincare formulations. Whether you’re formulating for dark spot correction, overall radiance, or sensitive skin, this peptide is your ideal solution.